Aim:
On the basis of emerging data about the association of vitamin D and coronary artery disease (CAD), we investigated whether a relationship exists among vitamin D, inflammation represented by C-reactive protein (CRP), and serum lipid profile in CAD.
Materials and Methods:
Patients with newly diagnosed CAD (n = 115) and 62 healthy subjects were enrolled in the study. Blood lipids, CRP, and vitamin D levels were measured, and the patient and control groups’ values were compared.
Results:
The low-density lipoprotein cholesterol (LDL-C), triglyceride, and CRP levels were higher, and vitamin D and high-density lipoprotein cholesterol (HDL-C) levels were lower in the patient group. A positive correlation was found between the vitamin D and HDL-C levels (r=0.328; p<0.001) and a negative correlation was seen between vitamin D and CRP (r= -0.484; p<0.001). In the multivariate logistic regression analysis, smoking (p=0.001, OR = 5.301; 95% CI = 2.215 – 12.687), the presence of hypertension (p=0.040, OR = 2.355; 95% CI=1.039 – 5.336), LDL-C level (p=0.048, OR =1.021, 95% CI=1.000 – 1.042) and vitamin D level (p=0.001, OR = 0.937, 95% CI = 0.902 – 0.973) were found to be predictors of CAD.
Conclusion:
Decreased level of vitamin D is associated with presence and CAD. Decreased vitamin D levels are associated with low HDL-C and high CRP levels in CAD. Smoking, hypertension, LDL-C and vitamin D are predictors of CAD.
Keywords: 25-hydroxyvitamin D, coronary artery disease, high-density lipoprotein cholesterol, C-reactive protein, coronary angiography