Aim:

Type 2 diabetes mellitus (DM) characterized by target-tissue resistance to insülin and it is strongly linked to obesity. The adipocytes derived hormone resistin is involved in tip 2 DM, obesity, insülin resistance and iflammation. The aim of this study is to compare serum resistin levels between in normal glucose tolerance group (NGT), impaired glucose tolerance group (BGT) and Type 2 DM group and investigate correlations with obesity and insulin resistance.

Material and Methods:

Firstly, we compared serum concentrations of resistin with glucose,insülin,HbA1C, BMI,HOMA and waist-to-hip ratio in subject with NGT(n=25), BGT(n=23) and type 2 DM(n=24).Later, according to the body mass index(BMI) and homeostasis model assesment of insulin resistance(HOMA-IR) score 72 cases were divided into subgroups; nonobese with BMI<25 kg/²(43 cases), the obese with BMI>25kg/²(29 cases), HOMA-IR(+)(23 cases) and HOMA-IR(-)(49 cases). Fasting serum resistin level was measured by ELISA. Insulin resistance was measured by the(HOMA-IR) formula.

Results:

There was no statistical difference in resistin levels between NGT, BGT and Type 2 DM groups(p>0,05). Compared with non obese group, obese group showed higher serum resistin levels(p<0,01). HOMA score was found significantly higher in the BGT and Type 2 DM groups than NGT group(p<0,01). Between HOMA-IR(-) group and HOMA-IR(+) group no significant difference was observed between in the levels of resistin(p>0,05). A significant negative correlation observed between resistin and blood glucose waist-to-hip ratio (r=0,45,p<0,05) in NGT group, between resistin and fasting blood glucose, systolic blood pressure, age in BGT group (respectively;r=-0,45,p<05;r=-0,59,p<05;r=-0,53,p<0,01;r=0,46;r=0,45,p<0,05).

Conclusion:

We concluded that resistin may effect glucose metabolism, linked with obesity but indirectly effect insülin resistance and diabetes.

Keywords: Diabetes Mellitus, HOMA, obesity, resistin