Resistant hypertension is a problem widely seen in daily practice. The prevalence in studies ranges between 15% and 27%. The risk of cardiovascular diseases increases in patients with resistant hypertension despite the use of multiple antihypertensives in appropriate dosages and combinations compared to those with controlled hypertension. Resistance to antihypertensive therapy may be false or true. In evaluating these patients, causes of resistant hypertension must be excluded first, and factors capable of causing resistant hypertension must be subsequently considered on an individual basis.

The exclusion of false resistance to treatment consists of the determination and correction of factors contributing to hypertension and/or causes of secondary hypertension (SH), implementation of lifestyle changes and effective multidrug use.

When the underlying cause is correctly identified the possibility of treatment will be high, and unnecessary drug use by patients, exposure to complications and financial costs will be reduced.

We wish to discuss a case in which blood pressure was not regulated despite multiple antihypertensive drug use since the etiology of SH was not well investigated during monitoring.

Keywords: Resistant Hypertension, Obstructive sleep apnea syndrome, Diabetic Nephropathy