Abstract

In our study we aimed to contribute survelliance data espesially to increase awareness on treatment plannig for nosocomial meningitis.

Meterials and Methods

For this we collected data about 15519 cerebro-spinal fluid (CSF) patients with nosocomial and community based meningitis suspicion during six years. After culturing bacterias identification and susceptibility test made automatised system and susceptibility state evaluated according to CLSI standards.

Results

From a total of 10632 samples, 53% of them was male and 47% was female. Only 7% growth was from this samples. 23% and 76% of samples were from children and adolescent, respectively. CSF samples from community mostly gave growth to coagulase-negative staphilococci (CNS) (58%) and S. aureus (20%), while nosocomially isolated agents were as CNS (60%) and Acinetobacter spp. (11.4%). Despite CNS, Enterobacter spp.-mostly Klebsiella and Enterococcus growth from CSF samples were mostly isolated agents in children, in adolescents this order was as CNS and Acinetobacter spp. Predominance among gram positive agents isolated from CSF samples were CNS and S. aureus with resistance patern to penisillin and methicillin as 96% and 97%, and %83 and 36%. Resistance rates of S. pneumonia isolates to penicillin and ceftriaxone were as 18% and 5%, respectively; however ampicillin, penicillin, vancomycin resistance in enterococci were %52, %63 and %6, respectively. Mostly isolated agents from all samples as gram negative were Acinetobacter species with susceptibility rates of 40% to amikacin and 58% to meropenem in general.

Conclusion

We observed that distribution of menigitis causing microorganisms could be affected by presence of underlying factors.

Keywords: CSF, bacterial meningitis, antibiotic susceptibility