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Can Vitamin D Deficiency Predict Coronary Artery Disease?
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Research Article
VOLUME: 6 ISSUE: 2
P: 45-52
August 2018

Can Vitamin D Deficiency Predict Coronary Artery Disease?

Namik Kemal Med J 2018;6(2):45-52
Seref ALPSOY 1
Aydın AKYÜZ 1
Demet ÖZKARAMANLI GÜR 1
Birol TOPÇU 2
Hasan DEĞİRMENCİ 3
1. Namık Kemal Üniversitesi Tıp Fakültesi Kardiyoloji Kliniği Tekirdağ, Türkiye
2. Namık Kemal Üniversitesi Tıp Fakültesi Biyoistatistik AD, Tekirdağ, Türkiye
3. Tekirdağ Devlet Hastanesi, Kardiyoloji Kliniği Tekirdağ, Türkiye
No information available.
No information available
Received Date: 11.05.2018
Accepted Date: 13.06.2018
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ABSTRACT

Conclusion:

Decreased level of vitamin D is associated with presence and CAD. Decreased vitamin D levels are associated with low HDL-C and high CRP levels in CAD. Smoking, hypertension, LDL-C and vitamin D are predictors of CAD.

Results:

The low-density lipoprotein cholesterol (LDL-C), triglyceride, and CRP levels were higher, and vitamin D and high-density lipoprotein cholesterol (HDL-C) levels were lower in the patient group. A positive correlation was found between the vitamin D and HDL-C levels (r=0.328; p<0.001) and a negative correlation was seen between vitamin D and CRP (r= -0.484; p<0.001). In the multivariate logistic regression analysis, smoking (p=0.001, OR = 5.301; 95% CI = 2.215 – 12.687), the presence of hypertension (p=0.040, OR = 2.355; 95% CI=1.039 – 5.336), LDL-C level (p=0.048, OR =1.021, 95% CI=1.000 – 1.042) and vitamin D level (p=0.001, OR = 0.937, 95% CI = 0.902 – 0.973) were found to be predictors of CAD.

Materials and Methods:

Patients with newly diagnosed CAD (n = 115) and 62 healthy subjects were enrolled in the study. Blood lipids, CRP, and vitamin D levels were measured, and the patient and control groups’ values were compared.

Aim:

On the basis of emerging data about the association of vitamin D and coronary artery disease (CAD), we investigated whether a relationship exists among vitamin D, inflammation represented by C-reactive protein (CRP), and serum lipid profile in CAD.