ABSTRACT

Like many eukaryotes, DNA methylation is an important mechanism of epigenetic control in bacteria. Unlike eukaryotes, bacteria use DNA adenine methylation rather than DNA cytosine methylation as an epigenetic signal. Epigenetic mechanisms are thought to control several virulence factors of bacteria. Escherichia coli, Salmonella, Vibrio, Yersinia, Haemophilus, and Brucella are the mostly studied bacteria under that topic. Finding out how to control this gene expression in bacteria can facilitate the control of infections that may generate hope for the development of new options. Development of new drug molecules has become increasingly limited. As the number of molecular microbiology studies increase, it has been focused that bacteria virulence factors can be controlled by epigenetic mechanisms. Recently, the usage of Dam inhibitors for the treatment of infection and tumor suppression are the main questions focused on this topic.