EN | TR
E-ISSN: 2587-0262
The Association of Angiotension Converting Enzyme Gene Polimorphism with Prognosis of Henoch-Schönlein Purpura with Renal Involvement in the Children
PDF
Cite
Share
Request
Research Article
VOLUME: 8 ISSUE: 2
P: 191-196
August 2020

The Association of Angiotension Converting Enzyme Gene Polimorphism with Prognosis of Henoch-Schönlein Purpura with Renal Involvement in the Children

Namik Kemal Med J 2020;8(2):191-196
DOI: 10.37696/nkmj.695799
Sevliya ÖCAL DEMİR 1
Müferet ERGÜVEN 2
1. SB İstanbul Medeniyet Üniversitesi Göztepe Eğitim Araştırma Hastanesi, Çocuk Sağlığı ve Hastalıkları, Çocuk Enfeksiyon Hastalıkları, İstanbul, TÜRKİYE
2. Kafkas Üniversitesi Tıp Fakültesi, Çocuk Romatoloji, Kars, TÜRKİYE
No information available.
No information available
Received Date: 28.02.2020
Accepted Date: 08.06.2020
PDF
Cite
Share
Request

ABSTRACT

Aim:

Henoch-Schönlein purpura (HSP) is a vasculitis rarely progresses to renal failure. The mechanism of renal failure in HSP has been associated with increased angiotensin converting enzyme (ACE) activity and increased local angiotension-II concentration as a result of deletion in ACE gene. Here relation between ACE gene polymorphism and prognosis of HSP nephritis was investigated.

Materials and Methods:

Forty-two children with HSP nephritis and ACE gene polymorphism studied were included in the study. Those who have deletion (DD) allele (Group-1) and heterozygous deletion (ID) or insertion (II) allele (Group-2)) compared according to their demographic characteristic, severity of renal involvement.

Results:

Between two groups, there was no statically difference in the terms of age, gender distribution and duration of follow-up (p=0,347, p=422, p=0,267). In group-1, 11 cases had mild, 14 had moderate, 4 had severe renal involvement. In group-2 4 cases had mild, 8 had moderate and 1 had severe renal involvement. There was no statistically significant difference in severity of renal involvement between two groups (p=0,375). Although there was a difference in proteinuria recovery rates between the two groups, the number of cases was not enough for statistical analysis (p=0,127) [ID or II / ID (OR): 3,667, (95% Cl 0.619-21.739).

Conclusion:

There was no significant association between the severity of renal involvement of HSP with DD genotype or D allele, however, this needs to be supported by studies with larger series.