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Thyroid Functions and Autoantibodies in Vitiligo Patients in Istanbul Medeniyet University Göztepe Education and Research Hospital
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Research Article
VOLUME: 3 ISSUE: 3
P: 106-111
December 2015

Thyroid Functions and Autoantibodies in Vitiligo Patients in Istanbul Medeniyet University Göztepe Education and Research Hospital

Namik Kemal Med J 2015;3(3):106-111
Hayriye Erman 1
Aybala Erek Toprak 1
Sadettin Dürüyen 1
Alev Orhun 1
İncihan Ocakoglu 1
Mahir Cengiz 2
İlyas Duran 3
Ferruh Kemal İşman 1
1. İstanbul Medeniyet Üniversitesi Göztepe Eğitim ve Araştırma Hastanesi, Tıbbi Biyokimya, İstanbul, Türkiye
2. İstanbul Üniversitesi Cerrahpaşa Tıp Fakültesi Dahiliye Anabilim Dalı, İstanbul, Türkiye
3. Bingöl Kadın Doğum ve Çocuk Hastanesi, Tıbbi Biyokimya Laboratuvarı, Bingöl, Türkiye
No information available.
No information available
Received Date: 26.11.2015
Accepted Date: 11.12.2015
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ABSTRACT

Aim

Vitiligo is an acquired depigmentation disorder occurs with destruction of melanocytes, a common skin disease. Although many theories have been suggested for its pathogenesis, the role of autoimmunity is the most popular one. Our objective was to compare the prevalance of thyroid disorder, thyroid function tests and anti-thyroid peroxidase (anti-TPO), anti-thyroglobulin (anti-TG), vitamin B12 levels in vitiligo patients with healty subjects in Istanbul Medeniyet Uniersity (IMU) Göztepe Education And Research Hospital.

Material and Methods

A retrospective review of vitiligo patients admitted to the IMU Göztepe Education And Research Hospital dermatology outpatient clinic was conducted from january 1, 2013 to january 1, 2014. 298 cases of vitiligo (170 female and 128 male) and 40 control subjects (24 female and 16 male) were enrolled in this study. FT3, fT4, TSH, anti-TG and anti-TPO levels were measured by hormone analyzer.

Results

We detected various thyroid pathology and /or abnormal throid fuction tests 13% in patients group and 5.1% control group. Plasma level of anti-TG, anti-TPO( p<0,001, p<0,001 respectively) and Percent pozitivity of anti-TG and anti-TPO (p<0,01, p<0,001 respectively) were significantly higher in patients with vitiligo compared with healthy control. Anti-TPO was increased 23.7% anti-TG was increased 15,1% in patients group. Plasma level of vitamin B12 (p<0.01) were significantly lower in patients with vitiligo compared with healthy control.

Conclusion

According to our study, anti-TPO and anti-TG levels were shown to be significantly increased in vitiligo patients and vitamin B12 levels were shown to be decreased. We recommend periodical follow-up of vitiligo patients in terms of thyroid gland diseases.