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Correlation of Jitter Parameters and Acetylcholine Receptor Antibody Titers in Myasthenia Gravis
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Research Article
VOLUME: 8 ISSUE: 3
P: 450-455
December 2020

Correlation of Jitter Parameters and Acetylcholine Receptor Antibody Titers in Myasthenia Gravis

Namik Kemal Med J 2020;8(3):450-455
DOI: 10.37696/nkmj.759574
Ahmet Candan KÖYLÜOĞLU 1
Halit FİDANCI 2
İlker ÖZTÜRK 1
1. Adana City Training and Research Hospital, Department of Neurology, Adana, TURKEY
2. Adana City Training and Research Hospital, Department of Neurology, Division of Clinical Neurophysiology, Adana, TURKEY
No information available.
No information available
Received Date: 29.06.2020
Accepted Date: 28.10.2020
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ABSTRACT

Aim:

Acetylcholine receptor (AChR) antibody test and single-fiber electromyography (SFEMG) are two important tests for the diagnosis of myasthenia gravis (MG). In this study, it was aimed to find out whether there is a relationship between AChR antibody titers and stimulated SFEMG (SSFEMG) parameter.

Materials and Methods:

Patients whose clinical findings, repetitive nerve stimulation (RNS), and AChR antibody test were compatible with MG were included in this retrospective cohort study. The patients had to be newly diagnosed. SSFEMG was applied to the patients and SSFEMG parameters were analyzed.

Results:

Sixteen patients (11 males, 5 females) were included in the study. The mean age of the patients was 54.1 ± 15.8 years. AChR antibody positivity, abnormality in RNS and SSFEMG parameters were found in 13 (81%), 9 (56%), 14 (88%) patients, respectively. A significant positive correlation was found between serum AChR antibody level and the percentage of apparent single-fiber action potential (ASFAP) pairs with increased jitter (p=0.019, r=0.639).

Conclusion:

This study showed a positive correlation between AChR antibody titers and the percentage of ASFAP pairs with increased jitter obtained by SSFEMG.