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The Effects of Histological Grade Ratio on The Progression of High-Grade Non-Muscle Invasive Bladder Tumors
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Research Article
VOLUME: 8 ISSUE: 2
P: 271-278
August 2020

The Effects of Histological Grade Ratio on The Progression of High-Grade Non-Muscle Invasive Bladder Tumors

Namik Kemal Med J 2020;8(2):271-278
DOI: 10.37696/nkmj.730161
Meltem ÖZNUR 1
Murat AKGÜL 2
Ayşegül İSAL ARSLAN 1
Cenk Murat YAZICI 2
Enes ALTIN 2
1. Tekirdağ Namık Kemal University Faculty of Medicine, Pathology Department, Tekirdag, TURKEY
2. Tekirdağ Namık Kemal University Faculty of Medicine, Urology Department, Tekirdag, TURKEY
No information available.
No information available
Received Date: 30.04.2020
Accepted Date: 30.05.2020
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ABSTRACT

Results:

Seventy-four (80.4%) of the patients were reported as T1 and 18 (19.6%) as Ta. The mean ratio of high-grade findings was 11.9±8.5% and 69.5±28.1% for Ta and T1 patients, respectively(p<0.001). Three levels for classification of high degree ratio were determined as 25%, 50% and 75%. The number of patients with high degree ratio >25%, >50% and >75% was found to be 67(72.8%), 54(58.7%) and 43(46.7%), respectively. The high-grade ratio for >25% was in only 1 Ta patient while it was in 66 of the T1 patients(p<0.001). Forty-three patients (58.1%) in the T1 group were found to have a high-grade ratio >75%(p<0.001). Rate of progression was statistically higher in T1 patients with high-grade ratio greater than >50%(p=0.025).

Conclusion:

When evaluating the nuclear grade, defining tumors solely as high-grade leads to stratifying a highly heterogeneous population in a single group. Higher rate of progression is observed in NIMBT patients with high-grade ratio >50%.

Materials and Methods:

Ninety-two patients diagnosed with high grade NIMBT were analyzed between 2010-2018. Demographic information, tumor size, localization, multicentricity, and recurrence/progression situation were evaluated retrospectively. The high/low grade percentage ratio of tumor cells, tumor stage, differentiation, necrosis, lamina-propria invasion, lymphovascular invasion, and carcinoma in-situ presence were also examined by two uro-pathologist. The effect on tumor progression was evaluated with pathological findings.

Aim:

Histopathological classification is one of the main prognostic factors for non-muscle invasive bladder tumors (NMIBT). We evaluated the relationship between tumor progression and the ratio of high-grade differentiation plus other routine pathological parameters in NMIBT.